2025 NFL Season
NFL Week 6 picks & predictions
A pick for every game — the betting favorite with its implied win %, the pick against the spread, and how the PickemSZN crowd is leaning. See the full schedule & odds or the most popular picks.
Odds-favorite picks this week: 9–6 (60%)
SEA
4-2
20 – 12
Final
JAX
4-2
Odds pick
SEA 53% to win
Toss-up
Against the spread
SEA -1.5
Crowd pick
No picks yet
Odds pick hit ✓
CLE
1-5
9 – 23
Final
PIT
4-1
Odds pick
PIT 74% to win
Strong
Against the spread
PIT -6.5
Crowd pick
PIT 100%
Odds pick hit ✓
LAR
4-2
17 – 3
Final
BAL
1-5
Odds pick
BAL 71% to win
Solid
Against the spread
BAL -5.5
Crowd pick
LAR 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
LAC
4-2
29 – 27
Final
MIA
1-5
Odds pick
LAC 59% to win
Lean
Against the spread
LAC -2.5
Crowd pick
No picks yet
Odds pick hit ✓
CHI
3-2
25 – 24
Final
WSH
3-3
Odds pick
WSH 68% to win
Solid
Against the spread
WSH -4.5
Crowd pick
WSH 100%
Odds pick missed ✗
DAL
2-3-1
27 – 30
Final
CAR
3-3
Odds pick
DAL 55% to win
Toss-up
Against the spread
DAL -1.5
Crowd pick
DAL 100%
Odds pick missed ✗
BUF
4-2
14 – 24
Final
ATL
3-2
Odds pick
BUF 67% to win
Solid
Against the spread
BUF -4.5
Crowd pick
BUF 100%
Odds pick missed ✗
SF
4-2
19 – 30
Final
TB
5-1
Odds pick
TB 56% to win
Lean
Against the spread
TB -1.5
Crowd pick
TB 100%
Odds pick hit ✓
DEN
4-2
13 – 11
Final
NYJ
0-6
Odds pick
DEN 81% to win
Strong
Against the spread
DEN -7.5
Crowd pick
DEN 100%
Odds pick hit ✓
ARI
2-4
27 – 31
Final
IND
5-1
Odds pick
ARI 56% to win
Lean
Against the spread
ARI -1.5
Crowd pick
IND 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
CIN
2-4
18 – 27
Final
GB
3-1-1
Odds pick
GB 63% to win
Solid
Against the spread
GB -3
Crowd pick
GB 100%
Odds pick hit ✓
TEN
1-5
10 – 20
Final
LV
2-4
Odds pick
LV 64% to win
Solid
Against the spread
LV -3
Crowd pick
TEN 100%
Upset watch — crowd fading the favorite Odds pick hit ✓
DET
4-2
17 – 30
Final
KC
3-3
Odds pick
KC 59% to win
Lean
Against the spread
KC -2.5
Crowd pick
DET 66.7%
Upset watch — crowd fading the favorite Odds pick hit ✓
PHI
4-2
17 – 34
Final
NYG
2-4
Odds pick
PHI 81% to win
Strong
Against the spread
PHI -7
Crowd pick
PHI 100%
Odds pick missed ✗
NE
4-2
25 – 19
Final
NO
1-5
Odds pick
NE 67% to win
Solid
Against the spread
NE -3.5
Crowd pick
No picks yet
Odds pick hit ✓
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