Week 6 · 2025 NFL Season
San Francisco 49ers vs Tampa Bay Buccaneers
Sun, Oct 12, 2025, 4:25 PM EDT · CBS
Raymond James Stadium, Tampa
Final — Tampa Bay Buccaneers win
San Francisco 49ers visit the Tampa Bay Buccaneers at Raymond James Stadium in Week 6 of the 2025 NFL season. Final: San Francisco 49ers 19, Tampa Bay Buccaneers 30.
Betting lines
Moneyline
San Francisco 49ers: 2.10
Tampa Bay Buccaneers: 1.77
Spread
San Francisco 49ers: +1.5
Tampa Bay Buccaneers: -1.5
Over / Under
—
Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
Tampa Bay Buccaneers
- Benjamin Morrison (CB) — Questionable
- Bucky Irving (RB) — Questionable
- Ko Kieft (TE) — Questionable
- David Walker (LB) — Questionable
- JJ Roberts (S) — Questionable
Who's your pick?
Make your call on San Francisco 49ers vs Tampa Bay Buccaneers and every other game, free, and see how you stack up on the leaderboard.
Make your picks