2025 NFL Season
NFL Week 5 picks & predictions
A pick for every game — the betting favorite with its implied win %, the pick against the spread, and how the PickemSZN crowd is leaning. See the full schedule & odds or the most popular picks.
Odds-favorite picks this week: 5–9 (36%)
DEN
3-2
21 – 17
Final
PHI
4-1
Odds pick
PHI 68% to win
Solid
Against the spread
PHI -4.5
Crowd pick
PHI 100%
Odds pick missed ✗
SF
4-1
26 – 23
Final
LAR
3-2
Odds pick
LAR 56% to win
Lean
Against the spread
LAR -1.5
Crowd pick
LAR 100%
Odds pick missed ✗
LV
1-4
6 – 40
Final
IND
4-1
Odds pick
IND 56% to win
Lean
Against the spread
IND -1.5
Crowd pick
IND 100%
Odds pick hit ✓
TEN
1-4
22 – 21
Final
ARI
2-3
Odds pick
ARI 70% to win
Solid
Against the spread
ARI -5.5
Crowd pick
ARI 100%
Odds pick missed ✗
WSH
3-2
27 – 10
Final
LAC
3-2
Odds pick
LAC 56% to win
Lean
Against the spread
LAC -1.5
Crowd pick
LAC 100%
Odds pick missed ✗
NYG
1-4
14 – 26
Final
NO
1-4
Odds pick
NYG 56% to win
Lean
Against the spread
NYG -1.5
Crowd pick
NO 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
DET
4-1
37 – 24
Final
CIN
2-3
Odds pick
DET 55% to win
Toss-up
Against the spread
DET -1.5
Crowd pick
DET 100%
Odds pick hit ✓
MIA
1-4
24 – 27
Final
CAR
2-3
Odds pick
MIA 56% to win
Lean
Against the spread
MIA -1.5
Crowd pick
No picks yet
Odds pick missed ✗
DAL
2-2-1
37 – 22
Final
NYJ
0-5
Odds pick
DAL 59% to win
Lean
Against the spread
DAL -2.5
Crowd pick
No picks yet
Odds pick hit ✓
HOU
2-3
44 – 10
Final
BAL
1-4
Odds pick
BAL 78% to win
Strong
Against the spread
BAL -7.5
Crowd pick
No picks yet
Odds pick missed ✗
NE
3-2
23 – 20
Final
BUF
4-1
Odds pick
BUF 81% to win
Strong
Against the spread
BUF -8.5
Crowd pick
BUF 100%
Odds pick missed ✗
KC
2-3
28 – 31
Final
JAX
4-1
Odds pick
KC 68% to win
Solid
Against the spread
KC -4.5
Crowd pick
KC 100%
Odds pick missed ✗
MIN
3-2
21 – 17
Final
CLE
1-4
Odds pick
MIN 78% to win
Strong
Against the spread
MIN -7
Crowd pick
No picks yet
Odds pick hit ✓
TB
4-1
38 – 35
Final
SEA
3-2
Odds pick
TB 56% to win
Lean
Against the spread
TB -1.5
Crowd pick
SEA 100%
Upset watch — crowd fading the favorite Odds pick hit ✓
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