Week 5 · 2025 NFL Season
New England Patriots vs Buffalo Bills
Sun, Oct 5, 2025, 8:20 PM EDT · NBC
Highmark Stadium (Old), Orchard Park
Final — New England Patriots win
New England Patriots visit the Buffalo Bills at Highmark Stadium (Old) in Week 5 of the 2025 NFL season. Final: New England Patriots 23, Buffalo Bills 20.
Betting lines
Moneyline
New England Patriots: 4.20
Buffalo Bills: 1.24
Spread
New England Patriots: +8.5
Buffalo Bills: -8.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
New England Patriots
- Gabe Jacas (LB) — Questionable
- Julian Hill (TE) — Injured Reserve
- Quintayvious Hutchins (LB) — Questionable
Buffalo Bills
- Dorian Strong (CB) — Out
- Cole Bishop (S) — Questionable
- Dorian Williams (LB) — Questionable
- Ben VanSumeren (FB) — Questionable
- Tyler Bass (PK) — Questionable
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