Week 5 · 2025 NFL Season
San Francisco 49ers vs Los Angeles Rams
Thu, Oct 2, 2025, 8:15 PM EDT · Prime Video
SoFi Stadium, Inglewood
Final — San Francisco 49ers win
San Francisco 49ers visit the Los Angeles Rams at SoFi Stadium in Week 5 of the 2025 NFL season. Final: San Francisco 49ers 26, Los Angeles Rams 23.
Betting lines
Moneyline
San Francisco 49ers: 2.05
Los Angeles Rams: 1.80
Spread
San Francisco 49ers: +1.5
Los Angeles Rams: -1.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
Los Angeles Rams
- Eddie Walls III (LB) — Injured Reserve
- Kobie Turner (DE) — Questionable
- Shaun Dolac (LB) — Questionable
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