2021 NFL Season
NFL Week 16 picks & predictions
A pick for every game — the betting favorite with its implied win %, the pick against the spread, and how the PickemSZN crowd is leaning. See the full schedule & odds or the most popular picks.
Odds-favorite picks this week: 10–6 (63%)
SF
8-7
17 – 20
Final
TEN
10-5
Odds pick
SF 62% to win
Lean
Against the spread
Pick'em / no spread
Crowd pick
TEN 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
CLE
7-8
22 – 24
Final
GB
12-3
Odds pick
GB 77% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
GB 100%
Odds pick hit ✓
IND
9-6
22 – 16
Final
ARI
10-5
Odds pick
ARI 56% to win
Lean
Against the spread
Pick'em / no spread
Crowd pick
IND 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
DET
2-12-1
16 – 20
Final
ATL
7-8
Odds pick
ATL 72% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
ATL 100%
Odds pick hit ✓
PIT
7-7-1
10 – 36
Final
KC
11-4
Odds pick
KC 80% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
KC 100%
Odds pick hit ✓
BAL
8-7
21 – 41
Final
CIN
9-6
Odds pick
CIN 65% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
CIN 100%
Odds pick hit ✓
DEN
7-8
13 – 17
Final
LV
8-7
Odds pick
DEN 52% to win
Toss-up
Against the spread
Pick'em / no spread
Crowd pick
LV 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
BUF
9-6
33 – 21
Final
NE
9-6
Odds pick
NE 54% to win
Toss-up
Against the spread
Pick'em / no spread
Crowd pick
BUF 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
TB
11-4
32 – 6
Final
CAR
5-10
Odds pick
TB 79% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
CAR 100%
Upset watch — crowd fading the favorite Odds pick hit ✓
WSH
6-9
14 – 56
Final
DAL
11-4
Odds pick
DAL 81% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
DAL 100%
Odds pick hit ✓
LAC
8-7
29 – 41
Final
HOU
4-11
Odds pick
LAC 82% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
LAC 100%
Odds pick missed ✗
MIA
8-7
20 – 3
Final
NO
7-8
Odds pick
MIA 60% to win
Lean
Against the spread
Pick'em / no spread
Crowd pick
MIA 100%
Odds pick hit ✓
LAR
11-4
30 – 23
Final
MIN
7-8
Odds pick
LAR 64% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
LAR 100%
Odds pick hit ✓
NYG
4-11
10 – 34
Final
PHI
8-7
Odds pick
PHI 81% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
PHI 100%
Odds pick hit ✓
CHI
5-10
25 – 24
Final
SEA
5-10
Odds pick
SEA 73% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
SEA 100%
Odds pick missed ✗
JAX
2-13
21 – 26
Final
NYJ
4-11
Odds pick
NYJ 53% to win
Toss-up
Against the spread
Pick'em / no spread
Crowd pick
NYJ 100%
Odds pick hit ✓
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