Week 16 · 2021 NFL Season
Indianapolis Colts vs Arizona Cardinals
Sat, Dec 25, 2021, 8:15 PM EST
Final — Indianapolis Colts win
| 1 | 2 | 3 | 4 | T | |
|---|---|---|---|---|---|
| IND | 7 | 5 | 3 | 7 | 22 |
| ARI | 6 | 0 | 7 | 3 | 16 |
Indianapolis Colts visit the Arizona Cardinals in Week 16 of the 2021 NFL season. Final: Indianapolis Colts 22, Arizona Cardinals 16.
Recap: Banged-up Colts shrug off injuries, beat Cardinals 22-16 →
Prediction & pick
Odds pick
Arizona Cardinals
56% implied ·Lean
Against the spread
Pick'em / no spread
Crowd pick
Indianapolis Colts 100%
Odds pick missed ✗
The odds pick is simply the betting-line favorite; the crowd pick is how PickemSZN users are picking — not a proprietary model. See all Week 16 picks & predictions →
Betting lines
Moneyline
Indianapolis Colts: 2.26
Arizona Cardinals: 1.78
Spread
Indianapolis Colts: —
Arizona Cardinals: —
Over / Under
—
Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Team stats
IND ARI
20 1st Downs 20
346 Total Yards 378
220 Passing 245
126 Rushing 133
8-15 3rd down efficiency 6-13
5-40 Penalties 11-85
0 Turnovers 0
35:29 Possession 24:31
Leaders
IND
- Passing YardsCarson Wentz (QB) — 18/28, 225 YDS, 2 TD
- Rushing YardsJonathan Taylor (RB) — 27 CAR, 108 YDS
- Receiving YardsMichael Pittman Jr. (WR) — 8 REC, 82 YDS
ARI
- Passing YardsKyler Murray (QB) — 27/43, 245 YDS, 1 TD
- Rushing YardsKyler Murray (QB) — 4 CAR, 74 YDS
- Receiving YardsChase Edmonds (RB) — 8 REC, 71 YDS
Scoring summary
- Q1 6:11 IND T.Y. Hilton 1 Yd pass from Carson Wentz (Michael Badgley Kick) 7–0
- Q1 3:03 ARI Chase Edmonds 2 Yd Run (Matt Prater PAT failed) 7–6
- Q2 4:20 IND Penalty on Kyler Murray in End Zone for a Safety 9–6
- Q2 0:01 IND Michael Badgley 41 Yd Field Goal 12–6
- Q3 10:53 ARI Antoine Wesley 24 Yd pass from Kyler Murray (Matt Prater Kick) 12–13
- Q3 0:03 IND Michael Badgley 37 Yd Field Goal 15–13
- Q4 6:37 IND Dezmon Patmon 14 Yd pass from Carson Wentz (Michael Badgley Kick) 22–13
- Q4 0:42 ARI Matt Prater 28 Yd Field Goal 22–16
Standings
2025 AFC South Standings
| Team | W-L | PF | PA |
|---|---|---|---|
| Jacksonville | 13-4 | 474 | 336 |
| Houston | 12-5 | 404 | 295 |
| Indianapolis | 8-9 | 466 | 412 |
| Tennessee | 3-14 | 284 | 478 |
2025 NFC West Standings
| Team | W-L | PF | PA |
|---|---|---|---|
| Seattle | 14-3 | 483 | 292 |
| Los Angeles | 12-5 | 518 | 346 |
| San Francisco | 12-5 | 437 | 371 |
| Arizona | 3-14 | 355 | 488 |
Referee Craig Wrolstad
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