2021 NFL Season
NFL Week 1 picks & predictions
A pick for every game — the betting favorite with its implied win %, the pick against the spread, and how the PickemSZN crowd is leaning. See the full schedule & odds or the most popular picks.
Odds-favorite picks this week: 8–8 (50%)
MIN
0-1
24 – 27
Final
CIN
1-0
Odds pick
MIN 63% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
CIN 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
PHI
1-0
32 – 6
Final
ATL
0-1
Odds pick
ATL 63% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
ATL 100%
Odds pick missed ✗
ARI
1-0
38 – 13
Final
TEN
0-1
Odds pick
TEN 60% to win
Lean
Against the spread
Pick'em / no spread
Crowd pick
No picks yet
Odds pick missed ✗
SEA
1-0
28 – 16
Final
IND
0-1
Odds pick
SEA 98% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
SEA 100%
Odds pick hit ✓
SF
1-0
41 – 33
Final
DET
0-1
Odds pick
SF 76% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
SF 100%
Odds pick hit ✓
DEN
1-0
27 – 13
Final
NYG
0-1
Odds pick
DEN 58% to win
Lean
Against the spread
Pick'em / no spread
Crowd pick
NYG 100%
Upset watch — crowd fading the favorite Odds pick hit ✓
LAC
1-0
20 – 16
Final
WSH
0-1
Odds pick
LAC 53% to win
Toss-up
Against the spread
Pick'em / no spread
Crowd pick
LAC 100%
Odds pick hit ✓
CHI
0-1
14 – 34
Final
LAR
1-0
Odds pick
LAR 76% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
LAR 100%
Odds pick hit ✓
BAL
0-1
27 – 33
Final
LV
1-0
Odds pick
BAL 67% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
No picks yet
Odds pick missed ✗
JAX
0-1
21 – 37
Final
HOU
1-0
Odds pick
JAX 58% to win
Lean
Against the spread
Pick'em / no spread
Crowd pick
HOU 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
PIT
1-0
23 – 16
Final
BUF
0-1
Odds pick
BUF 72% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
BUF 100%
Odds pick missed ✗
GB
0-1
3 – 38
Final
NO
1-0
Odds pick
GB 98% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
No picks yet
Odds pick missed ✗
NYJ
0-1
14 – 19
Final
CAR
1-0
Odds pick
CAR 68% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
No picks yet
Odds pick hit ✓
DAL
0-1
29 – 31
Final
TB
1-0
Odds pick
TB 76% to win
Strong
Against the spread
Pick'em / no spread
Crowd pick
TB 100%
Odds pick hit ✓
MIA
1-0
17 – 16
Final
NE
0-1
Odds pick
NE 57% to win
Lean
Against the spread
Pick'em / no spread
Crowd pick
No picks yet
Odds pick missed ✗
CLE
0-1
29 – 33
Final
KC
1-0
Odds pick
KC 72% to win
Solid
Against the spread
Pick'em / no spread
Crowd pick
KC 100%
Odds pick hit ✓
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