2025 NFL Season
NFL Week 10 picks & predictions
A pick for every game — the betting favorite with its implied win %, the pick against the spread, and how the PickemSZN crowd is leaning. See the full schedule & odds or the most popular picks.
Odds-favorite picks this week: 8–6 (57%)
ATL
3-6
25 – 31
Final
IND
8-2
Odds pick
IND 76% to win
Strong
Against the spread
IND -6.5
Crowd pick
IND 100%
Odds pick hit ✓
LAR
7-2
42 – 26
Final
SF
6-4
Odds pick
LAR 71% to win
Solid
Against the spread
LAR -5.5
Crowd pick
LAR 100%
Odds pick hit ✓
NYG
2-8
20 – 24
Final
CHI
6-3
Odds pick
CHI 68% to win
Solid
Against the spread
CHI -4.5
Crowd pick
CHI 100%
Odds pick hit ✓
NE
8-2
28 – 23
Final
TB
6-3
Odds pick
TB 59% to win
Lean
Against the spread
TB -2.5
Crowd pick
TB 100%
Odds pick missed ✗
LV
2-7
7 – 10
Final
DEN
8-2
Odds pick
DEN 83% to win
Strong
Against the spread
DEN -9.5
Crowd pick
DEN 100%
Odds pick hit ✓
CLE
2-7
20 – 27
Final
NYJ
2-7
Odds pick
CLE 56% to win
Lean
Against the spread
CLE -1.5
Crowd pick
No picks yet
Odds pick missed ✗
BUF
6-3
13 – 30
Final
MIA
3-7
Odds pick
BUF 85% to win
Strong
Against the spread
BUF -9.5
Crowd pick
BUF 100%
Odds pick missed ✗
PHI
7-2
10 – 7
Final
GB
5-3-1
Odds pick
GB 54% to win
Toss-up
Against the spread
GB -1.5
Crowd pick
PHI 100%
Upset watch — crowd fading the favorite Odds pick missed ✗
BAL
4-5
27 – 19
Final
MIN
4-5
Odds pick
BAL 68% to win
Solid
Against the spread
BAL -3.5
Crowd pick
No picks yet
Odds pick hit ✓
NO
2-8
17 – 7
Final
CAR
5-5
Odds pick
CAR 71% to win
Solid
Against the spread
CAR -5.5
Crowd pick
CAR 100%
Odds pick missed ✗
JAX
5-4
29 – 36
Final
HOU
4-5
Odds pick
JAX 53% to win
Toss-up
Against the spread
JAX -1.5
Crowd pick
JAX 100%
Odds pick missed ✗
DET
6-3
44 – 22
Final
WSH
3-7
Odds pick
DET 83% to win
Strong
Against the spread
DET -8.5
Crowd pick
DET 100%
Odds pick hit ✓
PIT
5-4
10 – 25
Final
LAC
7-3
Odds pick
LAC 61% to win
Lean
Against the spread
LAC -3
Crowd pick
No picks yet
Odds pick hit ✓
ARI
3-6
22 – 44
Final
SEA
7-2
Odds pick
SEA 78% to win
Strong
Against the spread
SEA -7
Crowd pick
SEA 100%
Odds pick hit ✓
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