Week 15 · 2025 NFL Season
Tennessee Titans vs San Francisco 49ers
Sun, Dec 14, 2025, 4:25 PM EST · FOX
Levi's Stadium, Santa Clara
Final — San Francisco 49ers win
Tennessee Titans visit the San Francisco 49ers at Levi's Stadium in Week 15 of the 2025 NFL season. Final: Tennessee Titans 24, San Francisco 49ers 37.
Betting lines
Moneyline
Tennessee Titans: 7.00
San Francisco 49ers: 1.11
Spread
Tennessee Titans: +12.5
San Francisco 49ers: -12.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
Tennessee Titans
- Jeffery Simmons (DT) — Questionable
- C.J. Ravenell (DE) — Injured Reserve
- Oluwafemi Oladejo (DE) — Questionable
- Marcus Harris (CB) — Questionable
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
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