Week 1 · 2025 NFL Season
San Francisco 49ers vs Seattle Seahawks
Sun, Sep 7, 2025, 4:05 PM EDT · FOX
Lumen Field, Seattle
Final — San Francisco 49ers win
San Francisco 49ers visit the Seattle Seahawks at Lumen Field in Week 1 of the 2025 NFL season. Final: San Francisco 49ers 17, Seattle Seahawks 13.
Betting lines
Moneyline
San Francisco 49ers: 1.76
Seattle Seahawks: 2.12
Spread
San Francisco 49ers: -1.5
Seattle Seahawks: +1.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
Seattle Seahawks
- Zach Charbonnet (RB) — Questionable
- Tory Horton (WR) — Questionable
- AJ Barner (TE) — Questionable
- Kenny McIntosh (RB) — Questionable
- AJ Finley (S) — Questionable
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