Week 2 · 2025 NFL Season
San Francisco 49ers vs New Orleans Saints
Sun, Sep 14, 2025, 1:00 PM EDT · FOX
Caesars Superdome, New Orleans
Final — San Francisco 49ers win
San Francisco 49ers visit the New Orleans Saints at Caesars Superdome in Week 2 of the 2025 NFL season. Final: San Francisco 49ers 26, New Orleans Saints 21.
Betting lines
Moneyline
San Francisco 49ers: 1.32
New Orleans Saints: 3.50
Spread
San Francisco 49ers: -7
New Orleans Saints: +7
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
New Orleans Saints
- Devin Neal (RB) — Questionable
- Jordyn Tyson (WR) — Questionable
- Kendre Miller (RB) — Questionable
- Christen Miller (DT) — Questionable
- Nick Saldiveri (OT) — Out
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