Week 16 · 2025 NFL Season
San Francisco 49ers vs Indianapolis Colts
Mon, Dec 22, 2025, 8:15 PM EST · ESPN
Lucas Oil Stadium, Indianapolis
Final — San Francisco 49ers win
San Francisco 49ers visit the Indianapolis Colts at Lucas Oil Stadium in Week 16 of the 2025 NFL season. Final: San Francisco 49ers 48, Indianapolis Colts 27.
Betting lines
Moneyline
San Francisco 49ers: 1.39
Indianapolis Colts: 3.10
Spread
San Francisco 49ers: -5.5
Indianapolis Colts: +5.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
Indianapolis Colts
- Spencer Shrader (PK) — Questionable
- Daniel Jones (QB) — Questionable
- Alec Pierce (WR) — Questionable
- Charvarius Ward (CB) — Questionable
- Hunter Wohler (S) — Questionable
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