Week 8 · 2025 NFL Season
San Francisco 49ers vs Houston Texans
Sun, Oct 26, 2025, 1:00 PM EDT · FOX
NRG Stadium, Houston
Final — Houston Texans win
San Francisco 49ers visit the Houston Texans at NRG Stadium in Week 8 of the 2025 NFL season. Final: San Francisco 49ers 15, Houston Texans 26.
Betting lines
Moneyline
San Francisco 49ers: 2.10
Houston Texans: 1.77
Spread
San Francisco 49ers: +2.5
Houston Texans: -2.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
Houston Texans
- Tank Dell (WR) — Questionable
- Layne Pryor (TE) — Questionable
- Logan Hall (DE) — Questionable
- Marlin Klein (TE) — Questionable
- Brevin Jordan (TE) — Questionable
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