Week 13 · 2025 NFL Season
San Francisco 49ers vs Cleveland Browns
Sun, Nov 30, 2025, 1:00 PM EST · CBS
Huntington Bank Field, Cleveland
Final — San Francisco 49ers win
San Francisco 49ers visit the Cleveland Browns at Huntington Bank Field in Week 13 of the 2025 NFL season. Final: San Francisco 49ers 26, Cleveland Browns 8.
Betting lines
Moneyline
San Francisco 49ers: 1.40
Cleveland Browns: 3.05
Spread
San Francisco 49ers: -5.5
Cleveland Browns: +5.5
Over / Under
—
Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
Cleveland Browns
- Harold Fannin Jr. (TE) — Questionable
- Jerry Jeudy (WR) — Questionable
- Quinshon Judkins (RB) — Questionable
- Denzel Ward (CB) — Questionable
- Mason Graham (DT) — Questionable
Who's your pick?
Make your call on San Francisco 49ers vs Cleveland Browns and every other game, free, and see how you stack up on the leaderboard.
Make your picks