Week 11 · 2025 NFL Season
San Francisco 49ers vs Arizona Cardinals
Sun, Nov 16, 2025, 4:05 PM EST · FOX
State Farm Stadium, Glendale
Final — San Francisco 49ers win
San Francisco 49ers visit the Arizona Cardinals at State Farm Stadium in Week 11 of the 2025 NFL season. Final: San Francisco 49ers 41, Arizona Cardinals 22.
Betting lines
Moneyline
San Francisco 49ers: 1.51
Arizona Cardinals: 2.64
Spread
San Francisco 49ers: -3.5
Arizona Cardinals: +3.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
Arizona Cardinals
- Kaleb Proctor (DT) — Questionable
- Tip Reiman (TE) — Questionable
- Karson Sharar (LB) — Questionable
- Walter Nolen III (DT) — Questionable
- Garrett Williams (CB) — Questionable
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