Week 5 · 2021 NFL Season
San Francisco 49ers vs Arizona Cardinals
Sun, Oct 10, 2021, 4:25 PM EDT
Final — Arizona Cardinals win
| 1 | 2 | 3 | 4 | T | |
|---|---|---|---|---|---|
| SF | 0 | 0 | 7 | 3 | 10 |
| ARI | 7 | 3 | 0 | 7 | 17 |
San Francisco 49ers visit the Arizona Cardinals in Week 5 of the 2021 NFL season. Final: San Francisco 49ers 10, Arizona Cardinals 17.
Recap: Cardinals use Hopkins, stellar defense to beat 49ers 17-10 →
Prediction & pick
Odds pick
Arizona Cardinals
69% implied ·Solid
Against the spread
Pick'em / no spread
Crowd pick
Arizona Cardinals 100%
Odds pick hit ✓
The odds pick is simply the betting-line favorite; the crowd pick is how PickemSZN users are picking — not a proprietary model. See all Week 5 picks & predictions →
Betting lines
Moneyline
San Francisco 49ers: 3.05
Arizona Cardinals: 1.45
Spread
San Francisco 49ers: —
Arizona Cardinals: —
Over / Under
—
Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Team stats
SF ARI
19 1st Downs 20
338 Total Yards 304
186 Passing 210
152 Rushing 94
3-11 3rd down efficiency 3-10
7-60 Penalties 6-62
1 Turnovers 1
31:54 Possession 28:06
Leaders
SF
- Passing YardsTrey Lance (QB) — 15/29, 192 YDS, 1 INT
- Rushing YardsTrey Lance (QB) — 16 CAR, 89 YDS
- Receiving YardsDeebo Samuel (WR) — 3 REC, 58 YDS
ARI
- Passing YardsKyler Murray (QB) — 22/31, 239 YDS, 1 TD
- Rushing YardsRondale Moore (WR) — 3 CAR, 38 YDS
- Receiving YardsDeAndre Hopkins (WR) — 6 REC, 87 YDS, 1 TD
Scoring summary
- Q1 9:02 ARI James Conner 1 Yd Run (Matt Prater Kick) 0–7
- Q2 5:27 ARI Matt Prater 21 Yd Field Goal 0–10
- Q3 1:42 SF Deebo Samuel 13 Yd Run (Joey Slye Kick) 7–10
- Q4 5:13 ARI DeAndre Hopkins 9 Yd pass from Kyler Murray (Matt Prater Kick) 7–17
- Q4 4:12 SF Joey Slye 47 Yd Field Goal 10–17
Standings
2025 NFC West Standings
| Team | W-L | PF | PA |
|---|---|---|---|
| Seattle | 14-3 | 483 | 292 |
| Los Angeles | 12-5 | 518 | 346 |
| San Francisco | 12-5 | 437 | 371 |
| Arizona | 3-14 | 355 | 488 |
Referee Clay Martin
Who's your pick?
Make your call on San Francisco 49ers vs Arizona Cardinals and every other game, free, and see how you stack up on the leaderboard.
Make your picks