Week 4 · 2025 NFL Season
New Orleans Saints vs Buffalo Bills
Sun, Sep 28, 2025, 1:00 PM EDT · CBS
Highmark Stadium (Old), Orchard Park
Final — Buffalo Bills win
New Orleans Saints visit the Buffalo Bills at Highmark Stadium (Old) in Week 4 of the 2025 NFL season. Final: New Orleans Saints 19, Buffalo Bills 31.
Betting lines
Moneyline
New Orleans Saints: 8.50
Buffalo Bills: 1.08
Spread
New Orleans Saints: +12.5
Buffalo Bills: -12.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
New Orleans Saints
- Devin Neal (RB) — Questionable
- Jordyn Tyson (WR) — Questionable
- Kendre Miller (RB) — Questionable
- Christen Miller (DT) — Questionable
- Nick Saldiveri (OT) — Out
Buffalo Bills
- Dorian Strong (CB) — Out
- Cole Bishop (S) — Questionable
- Dorian Williams (LB) — Questionable
- Ben VanSumeren (FB) — Questionable
- Tyler Bass (PK) — Questionable
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