Week 4 · 2025 NFL Season
Jacksonville Jaguars vs San Francisco 49ers
Sun, Sep 28, 2025, 4:05 PM EDT · FOX
Levi's Stadium, Santa Clara
Final — Jacksonville Jaguars win
Jacksonville Jaguars visit the San Francisco 49ers at Levi's Stadium in Week 4 of the 2025 NFL season. Final: Jacksonville Jaguars 26, San Francisco 49ers 21.
Betting lines
Moneyline
Jacksonville Jaguars: 3.00
San Francisco 49ers: 1.41
Spread
Jacksonville Jaguars: +5.5
San Francisco 49ers: -5.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
Jacksonville Jaguars
- Jourdan Lewis (CB) — Questionable
- Chris Rodriguez Jr. (RB) — Questionable
- Travis Hunter (WR) — Questionable
- Caleb Ransaw (CB) — Questionable
- Jalen McLeod (LB) — Questionable
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
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