Week 2 · 2025 NFL Season
Denver Broncos vs Indianapolis Colts
Sun, Sep 14, 2025, 4:05 PM EDT · CBS
Lucas Oil Stadium, Indianapolis
Final — Indianapolis Colts win
Denver Broncos visit the Indianapolis Colts at Lucas Oil Stadium in Week 2 of the 2025 NFL season. Final: Denver Broncos 28, Indianapolis Colts 29.
Betting lines
Moneyline
Denver Broncos: 1.54
Indianapolis Colts: 2.54
Spread
Denver Broncos: -3.5
Indianapolis Colts: +3.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
Denver Broncos
- Bo Nix (QB) — Questionable
- Caleb Lohner (TE) — Questionable
- Brandon Jones (S) — Questionable
- Drew Sanders (LB) — Questionable
- Matt Peart (OT) — Questionable
Indianapolis Colts
- Spencer Shrader (PK) — Questionable
- Daniel Jones (QB) — Questionable
- Alec Pierce (WR) — Questionable
- Charvarius Ward (CB) — Questionable
- Hunter Wohler (S) — Questionable
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