Week 12 · 2025 NFL Season
Carolina Panthers vs San Francisco 49ers
Mon, Nov 24, 2025, 8:15 PM EST · ESPN
Levi's Stadium, Santa Clara
Final — San Francisco 49ers win
Carolina Panthers visit the San Francisco 49ers at Levi's Stadium in Week 12 of the 2025 NFL season. Final: Carolina Panthers 9, San Francisco 49ers 20.
Betting lines
Moneyline
Carolina Panthers: 4.10
San Francisco 49ers: 1.25
Spread
Carolina Panthers: +7.5
San Francisco 49ers: -7.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
Carolina Panthers
- Tetairoa McMillan (WR) — Questionable
- Ikem Ekwonu (OT) — Questionable
- Thomas Incoom (LB) — Questionable
- Trevin Wallace (LB) — Questionable
- Tershawn Wharton (DT) — Questionable
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
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