Week 16 · 2025 NFL Season
Buffalo Bills vs Cleveland Browns
Sun, Dec 21, 2025, 1:00 PM EST · CBS
Huntington Bank Field, Cleveland
Final — Buffalo Bills win
Buffalo Bills visit the Cleveland Browns at Huntington Bank Field in Week 16 of the 2025 NFL season. Final: Buffalo Bills 23, Cleveland Browns 20.
Betting lines
Moneyline
Buffalo Bills: 1.15
Cleveland Browns: 5.70
Spread
Buffalo Bills: -10.5
Cleveland Browns: +10.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
Buffalo Bills
- Dorian Strong (CB) — Out
- Cole Bishop (S) — Questionable
- Dorian Williams (LB) — Questionable
- Ben VanSumeren (FB) — Questionable
- Tyler Bass (PK) — Questionable
Cleveland Browns
- Harold Fannin Jr. (TE) — Questionable
- Jerry Jeudy (WR) — Questionable
- Quinshon Judkins (RB) — Questionable
- Denzel Ward (CB) — Questionable
- Mason Graham (DT) — Questionable
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