Week 3 · 2025 NFL Season
Arizona Cardinals vs San Francisco 49ers
Sun, Sep 21, 2025, 4:25 PM EDT · FOX
Levi's Stadium, Santa Clara
Final — San Francisco 49ers win
Arizona Cardinals visit the San Francisco 49ers at Levi's Stadium in Week 3 of the 2025 NFL season. Final: Arizona Cardinals 15, San Francisco 49ers 16.
Betting lines
Moneyline
Arizona Cardinals: 2.64
San Francisco 49ers: 1.51
Spread
Arizona Cardinals: +3.5
San Francisco 49ers: -3.5
Over / Under
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Odds are decimal (from Betfair) and reflect the market as of the last update. How to read these →
Injury report
Arizona Cardinals
- Kaleb Proctor (DT) — Questionable
- Tip Reiman (TE) — Questionable
- Karson Sharar (LB) — Questionable
- Walter Nolen III (DT) — Questionable
- Garrett Williams (CB) — Questionable
San Francisco 49ers
- Mac Jones (QB) — Questionable
- Brandon Aiyuk (WR) — Out
- George Kittle (TE) — Questionable
- Darrick Forrest (S) — Injured Reserve
- Nick Bosa (DE) — Questionable
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